Article
Landscape and clinicopathologic features of RAS pathway mutations in chronic myelomonocytic leukemia.
Blood advances - 14 Oct 2025
Montalban-Bravo Guillermo, Loghavi Sanam, Li Ziyi, Chien Kelly, Kanagal-Shamanna Rashmi, Bataller Alex, Natu Anuya, Gurney Mark, Bazinet Alexandre, Hammond Danielle, Sasaki Koji, Borthakur Gautam, Swaminathan Mahesh, DiNardo Courtney, Kadia Tapan, Ravandi Farhad, Daver Naval, Short Nicholas, Pemmaraju Naveen, Issa Ghayas, Lasho Terra L, Finke Christy M, Al-Kali Aref, Csizmar Clifford, Alkhateeb Hassan, Gangat Naseema, Mangaonkar Abhishek A, Bueso-Ramos Carlos, Tefferi Ayalew, Kantarjian Hagop, Garcia-Manero Guillermo, Patnaik Mrinal M
Abstract excerpt
ABSTRACT: RAS pathway (RASp) mutations induce proliferative features, and promote transformation in chronic myelomonocytic leukemia (CMML). However, the unique clonal landscape and hierarchy of distinct RASp mutations remain unexplored. To characterize the landscape, architecture, and implications of unique RASp mutations in CMML, we evaluated a cohort of 814 patients with CMML. We identified 461 RASp mutations...
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