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Unraveling BRAF alterations: molecular insights to circumvent therapeutic resistance across cancer types

24 Mar 2025

Abstract excerpt

Aim: As intrinsic resistance - often driven by concurrent genomic alterations in tumor suppressor genes or oncogenes - remains a major challenge in oncology, this work aimed to comprehensively analyze BRAF somatic alterations across cancer types and identify new potential therapeutic strategies to overcome drug resistance. Methods: We conducted an extensive analysis of genomics, transcriptomics, and clinical data...

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PMID: 40201310
DOI: 10.20517/cdr.2024.213

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