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Article

BRAF Alterations in Chronic Lymphocytic Leukemia: Genomic Landscape, Co-Mutation Patterns, and Clinical Relevance.

Current hematologic malignancy reports - 1 May 2026

Al-Abdulmalek Abdulrahman, Landry Eric, Abdulgayoom Mohammed, Al-Mashdali Abdulrahman F, Dalol Ayman Abdullah, Muthanna Bassam, Routy Jean-Pierre, Mohamed Shehab F

Abstract excerpt

PURPOSE OF REVIEW: BRAF alterations are uncommon in chronic lymphocytic leukemia (CLL), yet increasing use of broad genomic profiling has identified them as a recurrent component of MAPK-pathway dysregulation. This revised review summarizes the reported frequency, mutation spectrum, co-mutation patterns, treatment-era associations, and clinical implications of BRAF alterations in adult CLL, with explicit...

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Topics

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Share to Antineoplastic Agents, Immunological
Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clinical Relevance

Share to Clonal Evolution

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to MAP Kinase Signaling System

Share to Molecular Targeted Therapy

Share to Neoplasm Recurrence, Local

Source

Open in PubMed Open full text

Identifiers

PMID: 42062666
DOI: 10.1007/s11899-026-00780-7
PMCID: PMC13132961

Genes

BRAF
BCL2
BTK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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