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Article

Syntaxin1A-mediated Resistance and Hypersensitivity to Isoflurane in Drosophila melanogaster.

Anesthesiology - 1 May 2015

Zalucki Oressia H, Menon Hareesh, Kottler Benjamin, Faville Richard, Day Rebecca, Bademosi Adekunle T, Lavidis Nickolas, Karunanithi Shanker, van Swinderen Bruno

Abstract excerpt

BACKGROUND: Recent evidence suggests that general anesthetics activate endogenous sleep pathways, yet this mechanism cannot explain the entirety of general anesthesia. General anesthetics could disrupt synaptic release processes, as previous work in Caenorhabditis elegans and in vitro cell preparations suggested a role for the soluble NSF attachment protein receptor protein, syntaxin1A, in mediating resistance to...

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Identifiers

PMID: 25738637
DOI: 10.1097/ALN.0000000000000629

Genes

NSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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