Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.

doi:10.1016/s0896-6273(00)80549-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly.

Neuron - 1 Aug 1998

Littleton J T, Chapman E R, Kreber R, Garment M B, Carlson S D, Ganetzky B

Abstract excerpt

The neuronal SNARE complex is formed via the interaction of synaptobrevin with syntaxin and SNAP-25. Purified SNARE proteins assemble spontaneously, while disassembly requires the ATPase NSF. Cycles of assembly and disassembly have been proposed to drive lipid bilayer fusion. However, this hypoth...

Topics

Amino Acid Sequence
Animals
Culture Techniques
Drosophila
Exocytosis
Membrane Proteins
Molecular Sequence Data
Mutation
Nerve Tissue Proteins
Neurotransmitter Agents
Paralysis
Qa-SNARE Proteins
Recombinant Proteins
SNARE Proteins
Sequence Homology, Amino Acid
Synapses
Synaptic Vesicles
Temperature

Source

Open in PubMed

Identifiers

PMID: 9728921
DOI: 10.1016/s0896-6273(00)80549-8

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9728921-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics