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Article

Isoflurane inhibits the neurotransmitter release machinery.

Journal of neurophysiology - 1 Aug 2009

Herring Bruce E, Xie Zheng, Marks Jeremy, Fox Aaron P

Abstract excerpt

Despite their importance, the mechanism of action of general anesthetics is still poorly understood. Facilitation of inhibitory GABA(A) receptors plays an important role in anesthesia, but other targets have also been linked to anesthetic actions. Anesthetics are known to suppress excitatory synaptic transmission, but it has been difficult to determine whether they act on the neurotransmitter release machinery...

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Identifiers

PMID: 19515956
DOI: 10.1152/jn.00252.2009
PMCID: PMC2724342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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