Article

Differential inhibition of GABA release from mouse hippocampal interneuron subtypes by the volatile anesthetic isoflurane

2020-10-02

Abstract excerpt

General anesthesia is critical to modern medicine and animal research, but the cellular and molecular actions of general anesthetics on the central nervous system remain poorly understood. Volatile anesthetics such as isoflurane disrupt synaptic transmission and inhibit synaptic vesicle release in a neurotransmitter-selective manner. For example, GABA release from interneurons is less sensitive to isoflurane inhib...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7849776d-04ba-58bc-ac0b-ba976ba80ba1
DOI: 10.1101/2020.10.01.308460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential inhibition of GABA release from mouse hippocampal interneuron subtypes by the volatile anesthetic isofluraneDOI 10.1101/2020.10.01.308460Read

Synapse-specific trapping of Syntaxin1a into nanoclusters by the general anesthetic isofluraneSemantic proximity Read

Isoflurane inhibits the neurotransmitter release machinery.Semantic proximity Read

Sevoflurane inhibition of the developmentally expressed neuronal sodium channel Na <sub>v</sub> 1.3Semantic proximity Read

Release your inhibitions: The cell biology of GABAergic postsynaptic plasticitySemantic proximity Read

Isoflurane Rescue Schizophrenia-related Deficits through Parvalbumin-positive Neurons in the Dentate GyrusSemantic proximity Read

Pyramidal neurons proportionately alter cortical interneuron subtypes.Semantic proximity Read

Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain.Semantic proximity Read

Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.Semantic proximity Read

Propofol Regulates Arousal by Enhancing Inhibitory Synaptic Transmission of Noradrenergic Neurons in the Locus Coeruleus of Adult Male MiceSemantic proximity Read

Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.Semantic proximity Read

Distinct nanoscale architectures of GABAergic inhibitory synapses predict diverse synaptic outputSemantic proximity Read

Expression patterns of GABAA receptor subtypes in developing hippocampal neurons.Semantic proximity Read