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Article

Functional variants in ATF4 and PMAIP1 reveal mitochondrial apoptosis dependencies driving pancreatic cancer progression.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jul 2026

Ali Syed Luqman, Ali Awais, Khatrawi Elham Mohammed, Kiran Rafia, Khan Bilal

Abstract excerpt

Pancreatic cancer is one of the most lethal malignancies worldwide, characterized by late diagnosis, aggressive progression, and poor survival. Dysregulation of regulated cell death (RCD) pathways, including apoptosis, ferroptosis, necroptosis, and mitochondrial dysfunction, contributes to tumor survival, therapy resistance, and immune evasion. Understanding the molecular mechanisms underlying these processes is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42024236
DOI: 10.1007/s00210-026-05355-0

Genes

ATF4
PMAIP1
ATF3
BCL2L1
GUK1
KCNMA1
SFN
SRC
TRADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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