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Article

The Noncoding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions.

Cancer research communications - 1 Oct 2025

Hayashi Akimasa, Ho Yu-Jui, Makohon-Moore Alvin P, Zucker Amanda, Hong Jungeui, Umeda Shigeaki, Karnoub Elias-Ramzey, Huang Jinlong, Baez Priscilla, Kappagantula Rajya, Melchor Jerry P, Park Wungki, O'Reilly Eileen M, Socci Nicholas D, Oki Shinya, Iacobuzio-Donahue Christine A

Abstract excerpt

While the coding genome of pancreatic cancer has been characterized in detail, features of the noncoding genome remain relatively unexplored. We used whole-genome sequencing to study the coding and noncoding genomes (promoters, enhancers, and noncoding-nonenhancer regions) in two unique patient cohorts. We find that treated cancers have a significantly higher mutational burden than untreated cancers in all four...

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Share to Enhancer Elements, Genetic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40971319
DOI: 10.1158/2767-9764.CRC-24-0167
PMCID: PMC12531768

Genes

KLF5
TP63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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