Article

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis

2024-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid cancers and thus identifying more effective therapies is a major unmet need. In this study we characterized the super enhancer (SE) landscape of human PDAC to identify novel, potentially targetable, drivers of the disease. Our analysis revealed that MICAL2 is a super enhancer-associated gene in human PDAC. MICAL2 is a fl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 259bfa80-7b02-5379-9a56-cfed2c81188a
DOI: 10.1101/2024.06.26.600548

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and MetastasisDOI 10.1101/2024.06.26.600548Read

MICAL2 Promotes Pancreatic Cancer Growth and MetastasisSemantic proximity Read

Mena (ENAH) Promotes KRAS-Driven Tumor Growth and Metastatic Progression in Pancreatic Ductal AdenocarcinomaSemantic proximity Read

Oncogenic signaling pathways in pancreatic ductal adenocarcinoma.Semantic proximity Read

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancerSemantic proximity Read

The oncofetal protein IMP1 regulates the transcriptomic landscape to drive early events in pancreatic cancer progression and growthSemantic proximity Read

Spatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration.Semantic proximity Read

Integrated transcriptional analysis reveals macrophage heterogeneity and tumor-macrophage interactions in the progression of pancreatic ductal adenocarcinomaSemantic proximity Read

Klf4-Tymp axis promotes inflammation-driven early tumorigenesis by enhancing kras mutation-induced acinar-to-ductal metaplasia through Pi3k/Akt and Mek/Erk pathways.Semantic proximity Read

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancerSemantic proximity Read

Multi-omic characterization of MAP4 in pancreatic adenocarcinoma progression: epitranscriptomic networks, EMT Activation, and stromal-immune dynamicsSemantic proximity Read

eIF4G2-dependent translation restrains pancreatic cancer progressionSemantic proximity Read

Molecular mechanisms of RACK1-driven metastasis in pancreatic ductal adenocarcinoma revealed by single-cell RNA sequencingSemantic proximity Read