Article
Chromatin Looping Shapes KLF5-Dependent Transcriptional Programs in Human Epithelial Cancers.
Cancer research - 15 Dec 2020
Liu Yanli, Guo Bingqian, Aguilera-Jimenez Estrella, Chu Vivian S, Zhou Jin, Wu Zhong, Francis Joshua M, Yang Xiaojun, Choi Peter S, Bailey Swneke D, Zhang Xiaoyang
Abstract excerpt
Activation of transcription factors is a key driver event in cancer. We and others have recently reported that the Krüppel-like transcription factor KLF5 is activated in multiple epithelial cancer types including squamous cancer and gastrointestinal adenocarcinoma, yet the functional consequences and the underlying mechanisms of this activation remain largely unknown. Here we demonstrate that activation of KLF5...
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