Article

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

2022-10-28

Abstract excerpt

Objective: Norepinephrine stimulates the adipose tissue thermogenic program through a β-adrenergic receptor (βAR) - cyclic adenosine monophosphate (cAMP) - protein kinase A (PKA) signaling cascade. We discovered that a noncanonical activation of the mechanistic target of rapamycin complex 1 (mTORC1) by PKA is required for the βAR-stimulation of adipose tissue browning. However, the downstream events triggered by P...

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Literature Corpus work: bdad5f4f-d91a-5d3b-a21f-3798a87bf3d9
DOI: 10.1101/2022.10.27.514130

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