Article

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

2019-10-29

Abstract excerpt

Brown adipose tissue (BAT) is composed of thermogenic cells that convert chemical energy into heat to help maintain a constant body temperature and counteract metabolic disease in mammals. The metabolic adaptations required for thermogenesis are not fully understood. Here we explore how steady state levels of metabolic intermediates are altered in brown adipose tissue in response to cold exposure. Transcriptome an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea1c4c5d-ad8a-57a1-b5b6-e5bcb4b205ad
DOI: 10.1101/823799

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesisDOI 10.1101/823799Read

Brown, beige, and white: the new color code of fat and its pharmacological implications.Semantic proximity Read

A Cold-Responsive Mitochondrial Transporter Stimulates Brown Adipose Tissue ThermogenesisSemantic proximity Read

Ketone body driven lipid remodeling supports thermogenic adaptation to fastingSemantic proximity Read

Recent advances in our understanding of brown and beige adipose tissue: the good fat that keeps you healthySemantic proximity Read

Mitochondrial ATP-Sensitive K <sup>+</sup> Channels (MitoK <sub>ATP</sub> ) Regulate Brown Adipocyte Differentiation and MetabolismSemantic proximity Read

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.Semantic proximity Read

The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans.Semantic proximity Read

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold ExposureSemantic proximity Read

Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenic response in subcutaneous adipose tissueSemantic proximity Read

Sweet science: Exploring the impact of fructose and glucose on brown adipocyte differentiation using optical diffraction tomographySemantic proximity Read

Impaired BCAA catabolism during adipocyte differentiation decreases glycolytic fluxSemantic proximity Read

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browningSemantic proximity Read