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Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats

2019-01-07

Abstract excerpt

<h4>AIM</h4> In this study, we investigated the role and mechanism of Salt-induced kinase 1 (SIK1) in regulation of hepatic glucose and lipid metabolism in a high-fat food (HFD) and streptozocin (STZ)-induced type 2 diabetes mellitus (T2DM) rat model. <h4>Methods</h4> A diabetic rat model treated with HFD plus low-dose STZ was developed and was transduced to induce a high expression of SIK1 in vivo via a tail-ve...

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Literature Corpus work
874f4f72-087f-57e6-9d0f-3172ed7babb9
DOI
10.1101/514299
Open publication

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