Article

Intermittent Hypoxia Drives Early Metabolic Dysfunction in Brown Adipose Tissue

2025-09-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Obstructive sleep apnea (OSA) is associated with metabolic dysfunction, yet the early impact of intermittent hypoxia (IH)—a defining feature of OSA—on brown adipose tissue (BAT) remains unclear. <h4>Methods</h4> We investigated the direct and early effects of IH on BAT using both in vitro and in vivo approaches. Differentiated mouse brown adipocytes were exposed to IH for 4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c0829b3-782f-5e2f-93d8-9d921a76c3fb
DOI: 10.1101/2025.09.18.676807

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intermittent Hypoxia Drives Early Metabolic Dysfunction in Brown Adipose TissueDOI 10.1101/2025.09.18.676807Read

Orai1-mediated Ca <sup>2+</sup> Entry Regulates Lipolysis and Mitochondrial Activation in Brown Adipose ThermogenesisSemantic proximity Read

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary diseaseSemantic proximity Read

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary diseaseSemantic proximity Read

AQP1- A regulatory factor associated with brown adipose tissue-silencingSemantic proximity Read

Cell-Specific Transcriptomic and Mito-Nuclear Imbalance in Lungs Under Intermittent Hypoxia in Adult Male MiceSemantic proximity Read

Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance DevelopmentSemantic proximity Read

Inhibition of Lipolysis Ameliorates Diabetic Phenotype in a Mouse Model of Obstructive Sleep Apnea.Semantic proximity Read

Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibilitySemantic proximity Read

Shifts of Immune Cell Populations Differ in Response to Different Effectors of Beige Remodeling of Adipose TissueSemantic proximity Read

Molecular and cellular regulation of thermogenic fatSemantic proximity Read

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold ExposureSemantic proximity Read

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogrammingSemantic proximity Read