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Article

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

8 Feb 2016

Abstract excerpt

Rapamycin extends life span in mice, yet paradoxically causes lipid dysregulation and glucose intolerance through mechanisms that remain incompletely understood. Whole-body energy balance can be influenced by beige/brite adipocytes, which are inducible by cold and other stimuli via β-adrenergic signaling in white adipose depots. Induction of beige adipocytes is considered a promising strategy to combat obesity...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 26858361
DOI: 10.2337/db15-0502

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