Article

Orai1-mediated Ca <sup>2+</sup> Entry Regulates Lipolysis and Mitochondrial Activation in Brown Adipose Thermogenesis

2026-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Cold-induced thermogenesis in brown adipose tissue (BAT) is essential for maintaining energy homeostasis, yet the Ca 2+ -dependent mechanisms underlying this process remain incompletely understood. Here, we identify Orai1, a component of the store-operated Ca 2+ entry pathway, as a regulator of thermogenic activation in BAT. Using a brown adipocyte-specific Orai1 knockout mouse model, we demo...

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Literature Corpus work: fd5898ba-de3c-5bea-915d-90ac183ad3dc
DOI: 10.64898/2026.04.24.718619

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