Article

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

2022-11-22

Abstract excerpt

Maintaining mitochondrial function is critical to an improved health span and lifespan. Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial unfolded protein response (UPR mt ) and increases lifespan in several animal models. Notably, lower mitochondrial ribosomal protein (MRP) expression also correlates with increased lifespan in a reference population of mice. In this study,...

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Literature Corpus work: bdabcea5-3181-5a0a-8a0c-102d817ac340
DOI: 10.21203/rs.3.rs-2271831/v1

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