Article
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.
Cell metabolism - 14 Jun 2016
Mitchell Sarah J, Madrigal-Matute Julio, Scheibye-Knudsen Morten, Fang Evandro, Aon Miguel, González-Reyes José A, Cortassa Sonia, Kaushik Susmita, Gonzalez-Freire Marta, Patel Bindi, Wahl Devin, Ali Ahmed, Calvo-Rubio Miguel, Burón María I, Guiterrez Vincent, Ward Theresa M, Palacios Hector H, Cai Huan, Frederick David W, Hine Christopher, Broeskamp Filomena, Habering Lukas, Dawson John, Beasley T Mark, Wan Junxiang, Ikeno Yuji, Hubbard Gene, Becker Kevin G, Zhang Yongqing, Bohr Vilhelm A, Longo Dan L, Navas Placido, Ferrucci Luigi, Sinclair David A, Cohen Pinchas, Egan Josephine M, Mitchell James R, Baur Joseph A, Allison David B, Anson R Michael, Villalba José M, Madeo Frank, Cuervo Ana Maria, Pearson Kevin J, Ingram Donald K, Bernier Michel, de Cabo Rafael
Abstract excerpt
Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics...
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