Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR.

PLoS genetics - 1 Dec 2020

Amin Mustafi Raisa, Mahmud Siraje Arif, Dowgielewicz Jonathan L, Sapkota Madhab, Pellegrino Mark W

Abstract excerpt

Cells use a variety of mechanisms to maintain optimal mitochondrial function including the mitochondrial unfolded protein response (UPRmt). The UPRmt mitigates mitochondrial dysfunction by differentially regulating mitoprotective gene expression through the transcription factor ATFS-1. Since UPRmt activation is commensurate with organismal benefits such as extended lifespan and host protection during infection,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Diet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Resistance

Share to Longevity

Share to Mitochondrial Proteins

Share to Pseudomonas Infections

Share to Unfolded Protein Response

Share to Vitamin B 12

Source

Open in PubMed Open full text

Identifiers

PMID: 33338044
DOI: 10.1371/journal.pgen.1009234
PMCID: PMC7781476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR.PMID 33338044Read ↗

Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunitySemantic proximity Read ↗

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.Semantic proximity Read ↗

The paradox of mitochondrial dysfunction and extended longevity.Semantic proximity Read ↗

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type <i>C. elegans</i> strainsSemantic proximity Read ↗

Molecular mechanisms underlying genotype-dependent responses to dietary restriction.Semantic proximity Read ↗

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.Semantic proximity Read ↗

A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPRSemantic proximity Read ↗

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in miceSemantic proximity Read ↗

Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-DependentSemantic proximity Read ↗

Improved mitochondrial stress response in long‐lived Snell dwarf miceSemantic proximity Read ↗

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in miceSemantic proximity Read ↗

Genetic mapping of lifespan and mitochondrial stress response in C. elegansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.