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Article

Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice.

Communications biology - 8 Jun 2021

Moore James, Akbergenov Rashid, Nigri Martina, Isnard-Petit Patricia, Grimm Amandine, Seebeck Petra, Restelli Lisa, Frank Stephan, Eckert Anne, Thiam Kader, Wolfer David P, Shcherbakov Dimitri, Böttger Erik C

Abstract excerpt

Random errors in protein synthesis are prevalent and ubiquitous, yet their effect on organismal health has remained enigmatic for over five decades. Here, we studied whether mice carrying the ribosomal ambiguity (ram) mutation Rps2-A226Y, recently shown to increase the inborn error rate of mammalian translation, if at all viable, present any specific, possibly aging-related, phenotype. We introduced Rps2-A226Y...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34103648
DOI: 10.1038/s42003-021-02204-z
PMCID: PMC8187632

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