Article

Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

2022-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Maintaining mitochondrial function is critical to an improved health span and lifespan. Introducing mild stress by inhibiting mitochondrial translation invokes the mitochondrial unfolded protein response (UPR mt ) and increases lifespan in several animal models. Notably, lower mitochondrial ribosomal protein (MRP) expression also correlates with increased lifespan in a reference population of m...

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Literature Corpus work: 7109f4ac-e785-5e6c-bf4f-39ee05081eb7
DOI: 10.1101/2022.11.05.515295

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