Article
Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction.
PLoS genetics - 1 Mar 2015
Richman Tara R, Ermer Judith A, Davies Stefan M K, Perks Kara L, Viola Helena M, Shearwood Anne-Marie J, Hool Livia C, Rackham Oliver, Filipovska Aleksandra
Abstract excerpt
The evolutionary divergence of mitochondrial ribosomes from their bacterial and cytoplasmic ancestors has resulted in reduced RNA content and the acquisition of mitochondria-specific proteins. The mitochondrial ribosomal protein of the small subunit 34 (MRPS34) is a mitochondria-specific ribosomal protein found only in chordates, whose function we investigated in mice carrying a homozygous mutation in the nuclear...
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