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Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak

30 Sept 2020

Abstract excerpt

In genome evolution, genetic variants are the source of diversity, which natural selection acts upon.Treatment of human tuberculosis (TB) induces a strong selection pressure for the emergence of antibiotic resistance-conferring variants in the infecting Mycobacterium tuberculosis (MTB) strains.MTB evolution in response to treatment has been intensively studied and mainly attributed to point substitutions.However,...

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PMID: 32997707
DOI: 10.1371/journal.ppat.1008357

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