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Article

Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in <i>Mycobacterium tuberculosis</i>

2020-10-07

Abstract excerpt

Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline into TB drug regimens has improved treatment outcomes, but this advance is threatened by the emergence of strains of Mycobacterium tuberculosis ( Mtb ) resistant to bedaquiline. Clinical bedaquiline resistance is most frequently conferred by off-target resistance-associated variants (RAVs) i...

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Identifiers and source

Literature Corpus work
a0fe278c-0e76-525a-b178-c65cec56bd64
DOI
10.1101/2020.10.06.328799
Open publication

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Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in <i>Mycobacterium tuberculosis</i>DOI 10.1101/2020.10.06.328799
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