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The Role of Selection in Shaping Diversity of Natural M. tuberculosis Populations

15 Aug 2013

Abstract excerpt

Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), is estimated to infect a new host every second. While analyses of genetic data from natural populations of M.tb have emphasized the role of genetic drift in shaping patterns of diversity, the influence of natural selection on this successful pathogen is less well understood. We investigated the effects of natural selection on patterns of diversity...

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PMID: 23966858
DOI: 10.1371/journal.ppat.1003543

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