Article

Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation

2024-08-24

Abstract excerpt

The surveillance of translation is critical for the fitness of organisms from bacteria to humans. Ribosome-associated Quality Control (RQC) is a surveillance mechanism that promotes the elimination of truncated polypeptides, byproducts of ribosome stalling during translation. In canonical mammalian RQC, NEMF binds to the large ribosomal subunit and recruits the E3 ubiquitin ligase Listerin, which marks the nascent...

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Literature Corpus work: bda1b2ec-258f-56fd-8bcf-96008f6c52e3
DOI: 10.1101/2024.08.24.608776

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