Article
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009
Chu Jessie, Hong Nancy A, Masuda Claudio A, Jenkins Brian V, Nelms Keats A, Goodnow Christopher C, Glynne Richard J, Wu Hua, Masliah Eliezer, Joazeiro Claudio A P, Kay Steve A
Abstract excerpt
A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. lister encodes a RING finger protein, LISTERIN, which functions as an E3 ubiquitin ligase in vitro. Although lister is widely expressed in all tissues, motor and sensory neurons and neuronal...
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