Article

Hyperactive intestinal proteolysis underlies <i>smn-1</i> mutant phenotypes

2026-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Many neurological diseases are caused by mutations in broadly-expressed genes, but the basis for their neuron-specific manifestation is unclear. In Spinal Muscular Atrophy (SMA), loss of the ubiquitously-expressed spliceosome assembly factor SMN1 causes selective degeneration of motor neurons, leading to progressive neuromuscular decline. We explored the mechanisms of this cell-specific vulnera...

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Literature Corpus work: 616d1e80-9e0c-51ee-be05-0eab8c94bc06
DOI: 10.64898/2026.08.11.744262

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