A combinatorial extracellular code tunes the intracellular signaling network activity to distinct cellular responses

Abstract excerpt

<h4>SUMMARY</h4> Cells constantly survey a complex set of inputs that is processed by the intracellular signaling network, but little is known of how cells integrate input information from more than one cue. We employed a FRET biosensor-based imaging platform to study the effect of combinatorial growth factor levels on the signaling network in human cells. We found that pairwise stimuli caused distinct concentrat...

Topics

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• Carcinogens, Environmental
• Fluorescent Antibody Technique
• fms-Like Tyrosine Kinase 3
• MAP Kinase Signaling System
• Phosphoproteins
• ras Proteins
• Receptor Protein-Tyrosine Kinases
• STAT1 Transcription Factor

Identifiers and source

Literature Corpus work

bd92ce59-0efd-591c-ac3c-d67d3b7c7636

DOI

10.1101/346957