Article

Gene regulation gravitates towards either addition or multiplication when combining the effects of two signals

2020-05-27

Abstract excerpt

Signals often ultimately affect the transcription of genes, and often, two different signals can affect the transcription of the same gene. In such cases, it is natural to ask how the combined transcriptional response compares to the individual responses. Mechanistic models can predict a range of combined responses, with the most commonly applied models predicting additive or multiplicative responses, but systemat...

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Literature Corpus work: be9ad931-b8b8-5e57-bc57-18de1a74a389
DOI: 10.1101/2020.05.26.116962

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