Article
Single cell profiling of potentiated phospho-protein networks in cancer cells.
Cell - 23 Jul 2004
Irish Jonathan M, Hovland Randi, Krutzik Peter O, Perez Omar D, Bruserud Øystein, Gjertsen Bjørn T, Nolan Garry P
Abstract excerpt
Altered growth factor responses in phospho-protein-driven signaling networks are crucial to cancer cell survival and pathology. Profiles of cancer cell signaling networks might therefore identify mechanisms by which such cells interpret environmental cues for continued growth. Using multiparameter flow cytometry, we monitored phospho-protein responses to environmental cues in acute myeloid leukemia at the single...
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