Article

Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss

2024-09-15

Abstract excerpt

Prion diseases are a group of rare and fatal neurodegenerative diseases caused by the cellular prion protein, PrP C , misfolding into the infectious form, PrP Sc , which forms aggregates in the brain. This leads to activation of glial cells, neuroinflammation, and irreversible neuronal loss, however, the role of glial cells in prion disease pathogenesis and neurotoxicity is poorly understood. Microglia can phago...

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Literature Corpus work: 19596ecc-b984-50db-8cfb-9c34be9ca8a1
DOI: 10.1101/2024.09.12.612597

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