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Article

Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

1 Jan 2013

Abstract excerpt

Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), is an abundant architectural chromosomal protein that has location-specific biological functions: within the nucleus as a DNA chaperone, within the cytosol to sustain autophagy and outside the cell as a DAMP...

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Identifiers

PMID: 24306421
DOI: 10.2119/molmed.2013.00099

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