Article

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation

2024-02-06

Abstract excerpt

The limited proliferative capacity of erythroid precursors is a major obstacle to generate sufficient numbers of in vitro-derived red blood cells (RBC) for clinical purposes. We and others have determined that BMI1, a member of the polycomb repressive complex 1 (PRC1), is both necessary and sufficient to drive extensive proliferation of self-renewing erythroblasts (SREs). However, the mechanisms of BMI1 action rem...

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Literature Corpus work: 999074a4-fc01-58e0-9c66-f2012648c1ac
DOI: 10.1101/2024.02.02.578704

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