Article

The lysosomal LAMTOR-Rag axis functions as a checkpoint for antiviral interferon production

2025-08-26

Abstract excerpt

<title>Abstract</title> <p>Lysosomes, best known for their nutrient-sensing and degradative roles, have emerged as essential hubs for antiviral defense. While higher organisms depend on type I interferon (IFN) induction for antiviral responses, the mechanism by which lysosomal signaling enables IFN-β production remains unclear. Here, we identify an evolutionarily repurposed lysosomal pathway—centered on the LAMTO...

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Literature Corpus work: 05d97968-1559-5cb6-a1b6-d8726b857952
DOI: 10.21203/rs.3.rs-5376814/v1

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