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Article

Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation

8 Apr 2021

Abstract excerpt

Antimalarial antibody responses are essential for mediating the clearance of Plasmodium parasite-infected RBCs from infected hosts. However, the rapid appearance of large numbers of plasmablasts in Plasmodium-infected hosts can suppress the development and function of durable humoral immunity. Here, we identify that the formation of plasmablast populations in Plasmodium-infected mice is mechanistically linked to...

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PMID: 33830176
DOI: 10.1084/jem.20202359

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