Article
Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
The Journal of experimental medicine - 4 Dec 2017
Tsai FuNien, Homan Philip J, Agrawal Hemant, Misharin Alexander V, Abdala-Valencia Hiam, Haines G Kenneth, Dominguez Salina, Bloomfield Christina L, Saber Rana, Chang Anthony, Mohan Chandra, Hutcheson Jack, Davidson Anne, Budinger G R Scott, Bouillet Philippe, Dorfleutner Andrea, Stehlik Christian, Winter Deborah R, Cuda Carla M, Perlman Harris
Abstract excerpt
The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway. We demonstrate that Bim acts as a molecular rheostat by controlling macrophage function not only in lymphoid organs but also in end organs, thereby preventing the break in tolerance. Mice lacking Bim in myeloid cells (LysMCreBimfl/fl) develop a systemic lupus erythematosus (SLE)-like disease that mirrors aged Bim-/- mice,...
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