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Longitudinal Investigation of Structural and Resting-State Effective Connectivity Alterations in a Non-Human Primate Model of Huntington’s Disease

2025-07-23

Abstract excerpt

Huntington’s disease (HD) is a genetic neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene which produce a mutant huntingtin (mHTT) protein that contributes to progressive striatal, cortical, and white-matter atrophy, resulting in motor dysfunction and cognitive decline. Recently, a non-human primate (NHP) model of HD was developed via stereotaxic delivery of an adeno-associated viral...

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Literature Corpus work
bd5cdd60-497a-5afb-8ee0-186ab8132e52
DOI
10.1101/2025.07.18.665554
Open publication

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