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A novel rhesus macaque model of Huntington’s disease recapitulates key neuropathological changes along with progressive motor and cognitive decline

2022-02-04

Abstract excerpt

<h4>ABSTRACT</h4> We created a new nonhuman primate model of the genetic neurodegenerative disorder, Huntington’s disease (HD), by injecting a mixture of recombinant adeno-associated viral vectors, serotypes AAV2 and AAV2.retro, each expressing a fragment of human mutant HTT ( mHTT) into the caudate and putamen of adult rhesus macaques. This novel modeling strategy results in robust expression of mutant hunting...

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Literature Corpus work
84337757-cc19-5e9b-a46d-259ca9013459
DOI
10.1101/2022.02.02.478920
Open publication

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