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Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review

21 Sept 2021

Abstract excerpt

Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbances. Neuropathological studies show that disease progression follows a characteristic pattern of brain atrophy, beginning in the basal ganglia structures. The HD...

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PMID: 34621236
DOI: 10.3389/fneur.2021.712555

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