Article

Resting-State fMRI reveals Longitudinal Alterations in Brain Network Connectivity in the zQ175DN mouse Model of Huntington's Disease

2023-01-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Huntington's diseaseis an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the CAG repeats in exon 1 of the huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atrophy result in the impairment of striatal and cortical circuits that affect the brain’s large-scale network functionality. However, the evol...

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Literature Corpus work: 0d9a7a21-b98e-5097-85b7-d8b07ff2067e
DOI: 10.21203/rs.3.rs-2370852/v1

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