Article

Timing of selective basal ganglia white matter loss in Huntington’s disease

2021-02-18

Abstract excerpt

<h4>Objectives</h4> To investigate the timeframe prior to symptom onset when cortico-basal ganglia white matter (WM) loss begins in premanifest Huntington’s disease (preHD), and which striatal and thalamic sub-region WM tracts are most vulnerable. <h4>Methods</h4> We performed fixel-based analysis, which allows resolution of crossing WM fibres at the voxel level, on diffusion tractography derived WM tracts of st...

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Literature Corpus work: 2a91b249-7a9f-59e8-b0f3-57d4df585476
DOI: 10.1101/2021.02.17.431568

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