Article

Defining Multiple Layers of Intratumor Heterogeneity Based on Variations of Perturbations in Multi-omics Profiling

2022-10-18

Abstract excerpt

Intratumor heterogeneity (ITH) is associated with tumor progression, relapse, immunoevasion, and drug resistance. Existing algorithms for measuring ITH are limited to at a single molecular level. We proposed a set of algorithms for measuring ITH at the genome (somatic copy number alterations (CNAs) and mutations), mRNA, microRNA (miRNA), long non-coding RNA (lncRNA), protein, and epigenome level, respectively. The...

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Literature Corpus work: bd5cb3e3-85bf-5d8e-a1de-454d6fd8c17b
DOI: 10.1101/2022.10.15.512357

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