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Article

DEPTH2: an mRNA-based algorithm to evaluate intratumor heterogeneity without reference to normal controls.

Journal of translational medicine - 1 Apr 2022

Song Dandan, Wang Xiaosheng

Abstract excerpt

BACKGROUND: Intratumor heterogeneity (ITH) is associated with tumor progression, unfavorable prognosis, immunosuppression, genomic instability, and therapeutic resistance. Thus, evaluation of ITH levels is valuable in cancer diagnosis and treatment. METHODS: We proposed a new mRNA-based ITH evaluation algorithm (DEPTH2) without reference to normal controls. DEPTH2 evaluates ITH levels based on the standard...

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Identifiers

PMID: 35365157
DOI: 10.1186/s12967-022-03355-1
PMCID: PMC8974098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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