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Article

An algorithm to quantify intratumor heterogeneity based on alterations of gene expression profiles.

Communications biology - 11 Sept 2020

Li Mengyuan, Zhang Zhilan, Li Lin, Wang Xiaosheng

Abstract excerpt

Intratumor heterogeneity (ITH) is a biomarker of tumor progression, metastasis, and immune evasion. Previous studies evaluated ITH mostly based on DNA alterations. Here, we developed a new algorithm (DEPTH) for quantifying ITH based on mRNA alterations in the tumor. DEPTH scores displayed significant correlations with ITH-associated features (genomic instability, tumor advancement, unfavorable prognosis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32917965
DOI: 10.1038/s42003-020-01230-7
PMCID: PMC7486929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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