Multi-omics integration defines an ECM-associated intratumoral heterogeneity signature enabling prognosis assessment and therapeutic stratification in hepatocellular carcinoma.

Abstract excerpt

Intratumoral heterogeneity (ITH) is a fundamental driver of hepatocellular carcinoma (HCC) progression and therapeutic resistance. Here, we developed a multi-omics-derived ITH scoring system to improve patient stratification and guide precision therapy. Using somatic mutation data from 361 TCGA HCC patients, we quantified genomic heterogeneity via the Mutant-Allele Tumor Heterogeneity (MATH) score, while...

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