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Integration of multi-omics approaches in exploring intra-tumoral heterogeneity

29 Aug 2025

Abstract excerpt

Intra-tumoral heterogeneity (ITH) is common in malignant tumors and arises from dynamic variations across genetic, epigenetic, transcriptomic, proteomic, metabolic, and microenvironmental factors. This complexity drives tumor evolution and treatment resistance, undermining the accuracy of clinical diagnosis, prognosis, and treatment planning. Despite recent advances in multi-omics technologies that enable...

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PMID: 40883767
DOI: 10.1186/s12935-025-03944-2

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