Heteromerization of alkaline-sensitive two-pore domain potassium channels

Abstract excerpt

Two-pore domain (K 2P ) potassium channels are active as dimers. They produce inhibitory currents regulated by a variety of stimuli. Among them, TALK1, TALK2 and TASK2 form a subfamily of structurally related K 2P channels stimulated by extracellular alkalosis. The human genes encoding them are clustered on chromosomal region 6p21. They are expressed in different tissues including the pancreas. By analyzing sing...

Topics

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• Adenosine Triphosphate
• ATP-Binding Cassette Transporters
• Cardiac Ischemia and Reperfusion
• Mutation
• Potassium Channels
• Potassium Channels, Inwardly Rectifying
• Receptors, Drug
• Sulfonylurea Receptors

Identifiers and source

Literature Corpus work

bd5bd65a-e3e3-5990-8990-2865ac7981a0

DOI

10.1101/2021.11.08.467666