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Article

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

Diabetes - 1 Mar 2022

Nichols Colin G, York Nathaniel W, Remedi Maria S

Abstract excerpt

Secretion of insulin from pancreatic β-cells is complex, but physiological glucose-dependent secretion is dominated by electrical activity, in turn controlled by ATP-sensitive potassium (KATP) channel activity. Accordingly, loss-of-function mutations of the KATP channel Kir6.2 (KCNJ11) or SUR1 (ABCC8) subunit increase electrical excitability and secretion, resulting in congenital hyperinsulinism (CHI), whereas...

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Identifiers

PMID: 35196393
DOI: 10.2337/db21-0755
PMCID: PMC8893938

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